The Coffin

The Coffin-Lowry syndrome.

The Coffin-Siris syndrome.

We report a white female infant with typical features of Coffin-Siris syndrome including thick eyebrows, flat nasal bridge, anteverted, wide nose tip, generalised hypertrichosis, scalp hypotrichosis, absence of the fifth fingernails and toenails, absence of the distal phalanges of the fifth fingers and of the second to fifth toes, small patellae, inguinal hernia, and sucking and feeding difficu...

The first nail in the coffin.

“It’s tinnitus. There’s nothing we can do for you. You’ll just have to learn to live with it.” Those words—so frequently uttered by an authority figure in a white coat—all too often hammer the first nail into the coffin of fear and despair in a person turning to a doctor for enlightenment and hope. As I see it, from a clinical perspective, we have three duties to patients presenting to us with ...

Coffin-Siris syndrome.

In 1970 Coffin and Siris described three unrelated female children with severe mental and developmental retardation, sparse scalp hair, and coarse appearing facies with bushy eyebrows, a wide mouth, and thick lips. There were, in addition, lax joints and brachydactyly of the fifth digits of both hands and feet with absence of the nails and terminal phalanges.' To our knowledge, there have been ...

One last nail in the MAPLEs coffin.